Grapes. Why? What do these have in common with a breath of air?

Below are the parts of the lungs where oxygen moves from the lungs into the blood. If the alveoli below were purple, they could resemble a bunch of grapes. Of course, as the alveoli are in the lungs, they must be very small to provide enough area for the exchange of gases. In fact, there are about 300 million alveoli in the adult lung.

Journey of a Breath of Air

Take in a big breath of air through your nose. As you inhale, you may feel the air pass down your throat and notice your chest expand. Now exhale and observe the opposite events occurring. Inhaling and exhaling may seem like simple actions, but they are just part of the complex process of respiration, which includes these four steps:

  1. Ventilation
  2. Pulmonary gas exchange
  3. Gas transport
  4. Peripheral gas exchange

Ventilation

Respiration begins with ventilation. This is the process of moving air in and out of the lungs. The lungs are the organs in which gas exchange takes place between blood and air.

Pulmonary Gas Exchange

Pulmonary gas exchange is the exchange of gases between inhaled air and the blood. It occurs in the alveoli of the lungs. Alveoli (singular, alveolus) are grape-like clusters surrounded by networks of thin-walled pulmonary capillaries. After you inhale, there is a greater concentration of oxygen in the alveoli than in the blood of the pulmonary capillaries, so oxygen diffuses from the alveoli into the blood across the capillaries (see Figure below). Carbon dioxide, in contrast, is more concentrated in the blood of the pulmonary capillaries than in the alveoli, so it diffuses in the opposite direction.

Alveoli are tiny sacs in the lungs where gas exchange takes place.

Gas Transport

After the blood in the pulmonary capillaries becomes saturated with oxygen, it leaves the lungs and travels to the heart. The heart pumps the oxygen-rich blood into arteries, which carry it throughout the body. Eventually, the blood travels into capillaries that supply body tissues. These capillaries are called peripheral capillaries.

Peripheral Gas Exchange

The cells of the body have a much lower concentration of oxygen than does the oxygenated blood in the peripheral capillaries. Therefore, oxygen diffuses from the peripheral capillaries into body cells. Carbon dioxide is produced by cells as a byproduct of cellular respiration, so it is more concentrated in the cells than in the blood of the peripheral capillaries. As a result, carbon dioxide diffuses in the opposite direction.

Back to the Lungs

The carbon dioxide from body cells travels in the blood from the peripheral capillaries to veins and then to the heart. The heart pumps the blood to the lungs, where the carbon dioxide diffuses into the alveoli. Then, the carbon dioxide passes out of the body through the other structures of the respiratory system, bringing the process of respiration full circle.

Gas Exchange and Homeostasis

Gas exchange is needed to provide cells with the oxygen they need for cellular respiration. Cells cannot survive for long without oxygen. Gas exchange is also needed to carry away carbon dioxide waste. Some of the carbon dioxide in the blood dissolves to form carbonic acid, which keeps blood pH within a normal range.

Blood pH may become unbalanced if the rate of breathing is too fast or too slow. When breathing is too fast, blood contains too little carbon dioxide and becomes too basic. When breathing is too slow, blood contains too much carbon dioxide and becomes too acidic. Clearly, to maintain proper blood pH, the rate of breathing must be regulated.

Further Reading

Regulation of Breathing

Summary

Review

  1. Outline the pathway of a breath of air from the nose to the alveoli.
  2. Describe how pulmonary gas exchange occurs.
  3. What is peripheral gas exchange.
  4. Sometimes people who are feeling anxious breathe too fast and become lightheaded. This is called hyperventilation. Hyperventilation can upset the pH balance of the blood, resulting in blood that is too basic. Explain why.